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伯豪生物榮獲：“10X Genomics 中國單細(xì)胞及空間組學(xué)優(yōu)選服務(wù)商”
科研技術(shù)服務(wù)平臺多樣 滿足不同樣本實(shí)驗(yàn)需求
▲伯豪生物（部分）技術(shù)平臺展示
| 序號 | 提供服務(wù) | 技術(shù)平臺 | 應(yīng)用方向 | 服務(wù)樣本保障 |
| 一 | 單細(xì)胞核 RNA 測序 【科研服務(wù)】 |
10X Genomics | ★冰凍組織。 ★FFPE 樣本。
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伯優(yōu)? 伯豪生物獨(dú)研 細(xì)胞核分離試劑盒 |
| 二 | 單細(xì)胞 RNA 測序 【科研服務(wù)】 |
1、高通量平臺： 10X Genomics；BD Rhapsody； 2、低通量平臺： SMART-seq 2。 |
★腫瘤異質(zhì)； ★腫瘤免疫微環(huán)境； ★胚胎發(fā)育； ★細(xì)胞分化。 （受細(xì)胞活率，懸液單胞率等影響）。 |
伯優(yōu)? 伯豪生物獨(dú)研 單細(xì)胞樣本保存液 無懼異地時(shí)效影響 |
| 三 | 單細(xì)胞 ATAC 測序 【科研服務(wù)】 |
10X Genomics | ★腫瘤異質(zhì)性； ★免疫微環(huán)境； ★神經(jīng)科學(xué)； ★胚胎發(fā)育； ★細(xì)胞分化等領(lǐng)域的研究。 |
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| 四 | 單細(xì)胞 TCR/BCR 測序 （單細(xì)胞免疫組庫測序） 【科研服務(wù)】 |
10X Genomics BD Rhapsody |
10X genomics 提供了全面的單細(xì)胞免疫分析方案； 通過精簡的工作流程，可以實(shí)現(xiàn)從樣品到文庫準(zhǔn)備、 免疫測序和軟件分析全套解決方案， 揭示 T 和 B 細(xì)胞多樣性、 V(D)J 重組和免疫細(xì)胞分析。 |
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| 五 | 單細(xì)胞 ATAC+RNA 測序 （單細(xì)胞多組學(xué)聯(lián)合） 【科研服務(wù)】 |
10X Genomics | ★干細(xì)胞； ★免疫； ★癌癥； ★神經(jīng)科學(xué)。 |
伯優(yōu)? 伯豪生物獨(dú)研 單細(xì)胞樣本保存液 無懼異地時(shí)效影響 |
| 六 | 單細(xì)胞全長轉(zhuǎn)錄本測序 【科研服務(wù)】 |
Nanopore | ★發(fā)現(xiàn)不同細(xì)胞攜帶的突變，攜帶突變的細(xì)胞與非突變 細(xì)胞相比，挖掘基因表達(dá)規(guī)律。 ★挖掘基因功能（如膜蛋白、分泌蛋白、轉(zhuǎn)錄因子等 編碼基因轉(zhuǎn)錄本使用情況，并發(fā)現(xiàn)全新功能的轉(zhuǎn)錄本）。 ★發(fā)現(xiàn)融合基因所在的細(xì)胞亞群，研究它們與腫瘤細(xì)胞 的擬時(shí)序分化關(guān)系。 ★發(fā)現(xiàn)亞群特異性的全新 lncRNA。 ★獲得亞群特異性表達(dá)的轉(zhuǎn)錄本，能夠輔助小核酸類藥 物開發(fā)企業(yè)等。 |
伯優(yōu)? 伯豪生物獨(dú)研 單細(xì)胞樣本保存液 無懼異地時(shí)效影響 |
| 七 | 空間轉(zhuǎn)錄組測序 【科研服務(wù)】 |
10X Genomics Visium | ★空間位置信息，或者細(xì)胞在組織中天然的狀態(tài)。 ★腫瘤學(xué)； ★免疫學(xué)； ★發(fā)育生物學(xué)； ★神經(jīng)科學(xué)； ★病理學(xué)等方向。 |
伯優(yōu)? 伯豪生物獨(dú)研 單細(xì)胞樣本保存液 無懼異地時(shí)效影響 |
| 八 | FFPE 空間轉(zhuǎn)錄組測序 【科研服務(wù)】 |
10X Genomics Visium | ★空間位置信息，或者細(xì)胞在組織中天然的狀態(tài)。 ★腫瘤學(xué)； ★免疫學(xué)； ★發(fā)育生物學(xué)； ★神經(jīng)科學(xué)； ★病理學(xué)等方向。 |
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| 伯豪生物 10X Genomics 儀器平臺 |
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| 儀器平臺名稱 | Chromium Controller | Chromium X |
| 原理 | Next GEM | Next GEM |
| 單次運(yùn)行樣本數(shù) | 8 | 16 |
| 捕獲細(xì)胞數(shù) | 500-10，000 | 2，000-20,000 |
| 捕獲效率 | 65% | 65% |
| 雙細(xì)胞率 | 0.8% per 1000 cells | 0.4% per 1000 cells |
| 兼容性 | 不兼容新試劑 | 兼容舊試劑 |
| 序號 | 協(xié)助客戶發(fā)表文章 | 雜志 | IF | 日期 | 樣本類型 |
| 1 | Characterization of Cancer Stem Cells 1 in Laryngea Squamous Cell Carcinoma by Single-cell RNA Sequencing | Genomics, Proteomics & Bioinformatics | 11.5 | 2024 Sep 6 | 人喉癌組織 |
| 2 | Disrupting YAP1-mediated glutamine metabolism induces synthetic lethality alongside ODC1 inhibition in osteosarcoma | CELLULAR ONCOLOGY | 4.9 | 2024 Aug 08 | 人細(xì)胞 |
| 3 | RAC1 inhibition ameliorates IBSP-induced bone metastasis in lung adenocarcinoma | Cell Reports | 7.5 | 2024 Jul 24 | 人肺癌骨轉(zhuǎn)移 |
| 4 | Single-cell RNA-seq reveals abnormal differentiation of keratinocytes and increased inflammatory differentiated keratinocytes in atopic dermatitis |
Journal of the European Academy of Dermatology and Venereology | 9.2 | 2023 Nov | 人皮膚 |
| 5 | Abnormal metabolism in melanocytes participates in the activation of dendritic cell in halo nevus | CLINICAL IMMUNOLOGY | 8.6 | 2024 Jun 29 | 人暈痣 |
| 6 | Activation of CD14+ Monocytes via the IFN-γ Signaling Pathway Is Associated with Immune-Related Adverse Events in Hepatocellular Carcinoma Patients Receiving PD-1 Inhibition Combination Therapy |
biomedicines | 3.9 | 2024 May 21 | 人外周血 |
| 7 | Distinct roles of TREM2 in central nervous system cancers and peripheral cancers | Cancer Cell | 50.3 | 2024 May 23 | 小鼠腦膠質(zhì)瘤 |
| 8 | Calcified apoptotic vesicles from PROCR+ fibroblasts initiate heterotopic ossification |
J Extracell Vesicles | 16 | 2024 Apr | 大鼠肌腱 |
| 9 | Landscape of gut mucosal immune cells showed gap of follicular or memory B cells into plasma cells in immunological non-responders | Clinical and Translational Medicine | 10.6 | 2024 May 23 | 人 Ileocyte 粘膜組織樣本 |
| 10 | Dissecting microenvironment in cystadenomas and hepatic cysts based on single nucleus RNA-sequencing data | COMPUTERS IN BIOLOGY AND MEDICINE | 7.7 | 2024 May 03 | 人肝囊腫 |
| 11 | Mapping cell diversity in human sporadic cerebral cavernous malformations | GENE | 3.5 | 2024 May 22 | 人石蠟樣本 |
| 12 | An advanced comprehensive muti-cell-type-specific model for predicting anti-PD-1 therapeutic effect in melanoma | Theranostics | 12.4 | 2024 Mar 03 | 人骨軟組織 |
| 13 | Heat shock protein gp96 drives natural killer cell maturation and anti-tumor immunity by counteracting Trim28 to stabilize Eomes | Nature Communications | 16.6 | 2024 Feb 06 | 小鼠脾細(xì)胞 |
| 14 | Deciphering the heterogeneity of neutrophil cells within circulation and the lung cancer microenvironment pre- and post-operation | CELL BIOLOGY AND TOXICOLOGY | 6.1 | 2024 Feb 06 | 人組織 / 血液 |
| 15 | Mrc1+ macrophage-derived IGF1 mitigates crystal nephropathy by promoting renal tubule cell proliferation via the AKT/Rb signaling pathway |
Theranostics | 12.4 | 2024 Feb 17 | 小鼠腎組織 |
| 16 | Radiotherapy-Induced Astrocyte Senescence Promotes anImmunosuppressive Microenvironment in Glioblastoma to Facilitate Tumor Regrowth | Advanced Science | 15.1 | 2024 Feb 11 | 小鼠大腦組織 |
| 17 | Single-cell transcriptomic analyses of tumor microenvironment and molecular reprograming landscape of metastatic laryngeal squamous cell carcinoma |
Communications Biology | 5.9 | 2024 Jan 08 | 喉癌組織 |
| 18 | Behind the Indolent Facade: Uncovering the Molecular Features and Malignancy Potential in Lung Minimally Invasive Adenocarcinoma by Single-Cell Transcriptomics |
Advanced Science | 15.1 | 2023 Nov 22 | 人肺癌組織 |
| 19 | Single-cell and spatial heterogeneity landscapes of mature epicardial cells | Journal of Pharmaceutical Analysis | 8.8 | 2023 Jul 22 | 小鼠心臟 |
| 20 | FOXG1 drives transcriptomic networks to specify principal neuron subtypes during the development of the medial pallium |
DEVELOPMENTAL NEUROSCIENCE | 13.116 | 2023 Mar 10 | 小鼠腦 |
| 21 | Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an antiferroptotic target in osteoarthritis |
EBioMedicine | 5.736 | 2022 Sep 19 | 人軟骨 |
| 22 | Microtubule stabilization targeting regenerative chondrocyte cluster for cartilage regeneration |
Theranostics | 8.579 | 2023 Jun 12 | 人軟骨 |
| 23 | Single-Cell Sequencing Informs That Mesenchymal Stem Cell Alleviates Renal Injury Through Regulating Kidney Regional Immunity in Lupus Nephritis |
STEM CELLS AND DEVELOPMENT | 4 | 2023 Aug 8 | 小鼠腎臟 |
| 24 | The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity | Cell Metabolism | 29 | 2023 Aug 04 | 結(jié)直腸癌組織 |
| 25 | Role and Therapeutic Potential for Targeting Fibroblast Growth Factor 10/FGFR1 in Relapsed Rheumatoid Arthritis | Arthritis and Rheumatology | 13.3 | 2023 Aug 16 | 人滑膜組織 |
| 26 | A single-cell transcriptional landscape of immune cells shows disease-specific changes of T cell and macrophage populations in human achalasia | Nature Communications | 16.6 | 2023 Aug 04 | 人食管下括約肌 & 血液 |
| 27 | Single-cell RNA sequencingreveals the Muller subtypes andinner blood-retinal barrierregulatory network in earlydiabetic retinopathy | Frontiers in Molecular Neuroscience | 6.261 | 2022 Dec 01 | 人視網(wǎng)膜 |
| 28 | Single-Nucleus Transcriptome Profiling of Locally Advanced Cervical Squamous Cell Cancer Identifies Neural-Like Progenitor Program Associated with the Efficacy of Radiotherapy |
Advanced Science | 15.1 | 2023 Jul 09 | 人宮頸腫瘤 |
| 29 | Updated skin transcriptomic atlas depicted by reciprocal contribution of single-nucleus RNA sequencing and single-cell RNA sequencing | JOURNAL OF DERMATOLOGICAL SCIENCE | 4.6 | 2023 Jun 20 | 人皮膚 |
| 30 | SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches | CELL RESEARCH | 46.297 | 2023 May 04 | 小鼠腿骨 |
| 31 | The role of signaling crosstalk of microglia in hippocampus on progression of ageing and Alzheimer’s disease | Journal of Pharmaceutical Analysis | 14.026 | 2023 May 15 | 小鼠海馬 |
| 32 | General anesthetic action profile on the human prefrontal cortex cells through comprehensive single-cell RNA-seq analysis | iScience | 6.107 | 2023 Apr 21 | 人大腦前額葉皮質(zhì)組織 |
| 33 | Single-cell RNA sequencing highlights intratumor heterogeneity and intercellular network featured in adamantinomatous craniopharyngioma |
SCIENCE ADVANCES | 14.957 | 2023 April 12 | 人顱咽管瘤 |
| 34 | Tumor microenvironment remodeling after neoadjuvant immunotherapy in non?small cell lung cancer revealed by single?cell RNA sequencing |
Genome Medicine | 15.266 | 2023 Mar 03 | 人血液 / 肺癌組織 |
| 35 | Identification of a tumour immune barrier in the HCC microenvironment that determines the efficacy of immunotherapy | Journal of Hepatology | 30.083 | 2023 Jan 25 | 人肝臟 |
| 36 | Single-cell RNA sequencing combined with single-cell proteomics identifies the metabolic adaptation of islet cell subpopulations to high-fat diet in mice |
Diabetologia | 10.46 | 2023 Jan | 小鼠胰腺 |
| 37 | Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity | Cell Reports | 9.995 | 2023 Jan 18 | 小鼠細(xì)胞 |
| 38 | Single-cell RNA-sequencing uncovers compound kushen injection synergistically improves the efficacy of chemotherapy by modulating the tumor environment of breast cancer |
Frontiers in Immunology | 8.786 | 2022 Oct 30 | 小鼠乳腺（癌）組織 |
| 39 | A YAP/TAZ-CD54 axis is required for CXCR2 ?CD44 ? tumor-specific neutrophils to suppress gastric cancer | Protein & Cell | 15.328 | 2022 Oct 26 | 人小鼠血液 |
| 40 | Single-cell dissection of remodeled inflammatory ecosystem in primary and metastatic gallbladder carcinoma |
Cell Discovery | 38.079 | 2022 Oct 05 | 人膽囊組織 |
| 41 | Defining Specific Cell States of MPTP-Induced Parkinson’s Disease by Single-Nucleus RNA Sequencing | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 6.208 | 2022 Sep 15 | 小鼠腦 |
| 42 | Single‐cell transcriptome atlas reveals protective characteristics of COVID‐19 mRNA vaccine |
Journal of Medical Virology | 20.693 | 2022 Sep 19 | 人肺組織 |
| 43 | Tumor-polarized GPX3+ AT2 lung epithelial cells promote premetastatic niche formation |
PNAS | 12.779 | 2022 Jul | 小鼠肺組織 |
| 44 | Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Acute Myocardial Infarction | frontiers in immunology | 8.786 | 2022 Jun 29 | 人外周血 |
| 45 | Brain single-nucleus transcriptomics highlights that polystyrene nanoplastics potentially induce Parkinson’s Disease-like neurodegeneration by causing energy metabolism disorders in mice | Journal Of Hazardous Materials | 14.224 | 2022 Feb 11 | 小鼠腦組織 |
| 46 | Patient-derived organoids for personalized gallbladder cancer modelling and drug screening |
Clinical and Translational Medicine | 8.554 | 2022 Jan | 人膽囊組織 |
| 47 | Anatlas of dynamic peripheral blood mononuclear cell landscapes in human perioperativeanaesthesia/surgery | Clinical and Translational Medicine | 8.554 | 2022 Jan | 人外周血 |
| 48 | Single-nucleus transcriptomic atlas of spinal cord neuron in human | Elife | 6.4 | 2021 Sep 30 | 人腦組織 |
| 49 | Single-cell RNA Sequencing Technology Revealed the Pivotal Role of Fibroblast Heterogeneity in Ang II-Induced Abdominal Aortic Aneurysms |
DNA AND CELL BIOLOGY | 3.55 | 2021 Nov | 小鼠腎上腹主動(dòng)脈 |
| 50 | iNKT subsets differ in their developmental and functional requirements on Foxo1 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 12.779 | 2021 Nov 16 | 小鼠骨髓 |
| 51 | Inherent hepatocytic heterogeneity determines expression and retention of edited F9 alleles post-AAV/CRISPR infusion | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 12.779 | 2022 Oct | 小鼠肝組織 |
| 52 | Single-cell profiling of tumor-infiltrating TCF1/TCF7 + T cells reveals a T lymphocyte subset associated with tertiary lymphoid structures/organs and a superior prognosis in oral cancer | ORAL ONCOLOGY | 5.972 | 2021 May 25 | 人口腔組織 |
| 53 | A novel recombinant cccDNA-based mouse model with long term maintenance of rcccDNA and antigenemia | Antiviral Res | 10.103 | 2020 Aug | 小鼠肝組織 |
| 54 | In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR–dCas9- activator transgenic mice |
Nature Neuroscience | 28.771 | 2018 Mar | 小鼠腦組織 |
| 55 | Single-cell transcriptomics reveals the landscape of intra-tumoral heterogeneity and transcriptional activities of ECs in CC | Molecular Therapy-Nucleic Acids | 10.183 | 2021 Apr 2 | 人宮頸癌組織 |
| 56 | A TNFR2-hnRNPK axis promotes primary liver cancer development via activation of YAP signaling in hepatic progenitor cells | Cancer Res | 13.312 | 2021 Feb 22 | 人肝組織 |
| 57 | Characterization of the heterogeneity of endothelial cells in bleomycin?induced lung fibrosis using single?cell RNA sequencing |
Angiogenesis | 10.658 | 2021 May | 小鼠肺組織 |
| 58 | Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain | Cell Research | 46.297 | 2021 Mar 10 | 小鼠腓腸神經(jīng) |
| 59 | Liver type 1 innate lymphoid cells develop locally via an interferon-g–dependent loop | Science | 63.714 | 2021 Mar 26 | 小鼠肝臟細(xì)胞 |
| 60 | Single-cell transcriptome atlas of lung adenocarcinoma featured with ground glass nodules | Cell Discovery | 38.079 | 2020 | 人肺癌組織 |
| 61 | Somatosensory neuron types identified by high-coverage single-cell RNA sequencing and functional heterogeneity | Cell Res | 46.297 | 2015 | 小鼠背根神經(jīng)節(jié) |
為什么要選擇伯豪生物？
1、伯豪生物按客戶需求真實(shí)開展實(shí)驗(yàn)，不辜負(fù)每一位客戶的傾心托付。
2、伯豪生物已通過 ISO9001:2015 國際質(zhì)量標(biāo)準(zhǔn)認(rèn)證，實(shí)驗(yàn)項(xiàng)目服務(wù)有保障。
3、伯豪生物實(shí)驗(yàn)團(tuán)隊(duì)項(xiàng)目經(jīng)驗(yàn)豐富，從樣本到數(shù)據(jù)，實(shí)驗(yàn)質(zhì)量有保障。
4、至今，風(fēng)雨兼程 15 載，伯豪生物與科研工作者共同攜手，累計(jì)發(fā)布 SCI 論文 2500 余篇。平均影響因子大于 7.2 分。
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